高品质异喹啉生产技术研究

Study on Production Techniques of High-quality Isoquinoline

文章简要介绍了目前异喹啉分离精制的工艺研究现状,在此基础上,提出了三步静态熔融结晶加一次精馏的生产方法,即把工业异喹啉经过三步熔融结晶提纯后,再通过精馏的手段对异喹啉产品进行提质,其中:静态熔融结晶工艺过程可将异喹啉提纯到≥98%,结晶工艺收率≥85%;而精馏提质所得异喹啉产品表现为无色透明状或白色结晶,水分含量≤0.05%,金属离子含量(包括钠、钾、铁、钙、镁等)均小于3 ppm,精馏工艺收率≥93%。

The article briefly described the current status of isolation and purification technology research of isoquinoline. On this basis, we proposed three-step static melt crystallization plus a distillation production method. Namely after three steps melt crystallization purification of the industrial isoquinoline, then by means of distillation of isoquinoline improved product quality. The results were as follows： static melt crystallization process could make isoquinoline purity higher than 98 %,the yield of crystallization process reached to 85 %; The performance of resulting distillation upgraded isoquinoline product was colorless transparent or white crystals, The moisture content was less than 0.05 %,the metal ion content （including sodium, potassium, iron, calcium, magnesium, etc.） were less than 3 ppm, and the yield of distillation process reached to 93 %.