热毒宁治疗慢性阻塞性肺病急性期的临床研究

Clinical Study of Reduning Treatment of Acute Exacerbation Phase of Chronic Obstructive Pulmonary Disease

目的探讨热毒宁治疗慢性阻塞性肺病急性期的疗效。方法 74例慢性阻塞性肺病患者随机分为实验组和对照组,每组37例。两组均给予常规治疗,实验组在此基础上给予热毒宁注射液治疗,两组均以10天为1个疗程,并随访1~2周,观察治疗前后两组患者治疗总有效率、FEV1/FVC、FEV占预计值百分比等指标及不良反应发生情况。结果实验组总有效率为81.08%,对照组为56.76%,两组比较,差异具有显著性（P〈0.05）;实验组在改善患者临床症状、肺功能等方面均优于对照组,差异具有显著性（P〈0.05）。结论热毒宁对慢性阻塞性肺病具有良好的治疗作用,能明显改善患者预后,值得临床推广应用。

Objective To investigate the efficacy and safety of Reduning treatment of acute exacerbation phase of chronic obstructive pulmonary. Methods A total of 74 patients with AECOPD were selected and divided randomly into two groups： a treatment group and one control group. The treatment group received Reduning（n=37） for 10 days, while the control group received conventional treatment（n=37） alone for the same duration, respectively, and follow-up of 1 to2 weeks. To observe the total effective rate of two groups of patients before and after the treatment、FEV1/FVC and FEV1/FVC, FEV take up of the expected target. Results The levels of lung function indexes and adverse drug reactions before and after treatment were compared between groups improved obviously after treatment（P〈0.05）. The response rates were 81.08% and 56.76% in treatment group and the control groups, respectively. There were significant differences between the two groups in improvement of clinical symptoms（P〈0.05）. Conclusion The treatment of Reduning has a good treatment effect in treatment of acute exacerbation phase of chronic obstructive pulmonary without adverse reaction.It is worthy of clinical application.