心型脂肪酸结合蛋白在心梗患者行介入治疗中的意义

Significance of Heart-type Fatty Acid Binding Protein in Interventional Therapy for Patients With Myocardial Infarction

目的研究分析心型脂肪酸结合蛋白对心梗患者介入治疗的应用情况,探讨患者使用经皮冠脉介入治疗对患者心型脂肪酸结合蛋白变化的影响。方法选取我院178例ST段抬高型心肌梗死患者来进行研究分析,将冠脉介入治疗后ST回落患者作为ST回落组,其余为ST无回落组。对患者的心型脂肪酸结合蛋白以及心肌肌钙蛋白进行测定,观察术后2小时ST回落幅度。结果两组患者术前无统计学差异性,术后6 h的心型脂肪酸结合蛋白均要优于术前。ST回落组患者的心型脂肪酸结合蛋白在24 h内恢复到正常状态,ST无回落组没有恢复正常状态。结论 ST抬高型心肌梗死患者的心型脂肪酸结合蛋白和冠脉病变程度有直接联系,手术会影响患者的心型脂肪酸结合蛋白水平,ST回落幅度超过50%以及心型脂肪酸结合蛋白降低到正常状态的患者,临床心肌损伤较轻,再灌注效果好。

Objective To study the applications of heart-type fatty acid binding protein in interventional treatment for patients with myocardial infarction, to explore the change of heart-type fatty acid binding protein（H-FABP） in patients with percutaneous coronary intervention（PCI）. Methods 178 cases of ST-segment elevation myocardial infarction patients were selected for research and analysis. After coronary intervention in patients with ST fall down as the ST group, the other for non-ST group. For patients with H-FABP and troponin（c Tn I） were measured, observed ST decline rate after two hours. Results There was no statistical difference between two groups, H-FABP after six hours was better than before surgery. H-FABP within 24 hours of ST group patients to return to a normal state, non-ST group did not fall back to normal state. Conclusion H-FABP of ST elevation myocardial infarction is directly linked to the severity of coronary artery disease. Surgery will affect the H-FABP levels in patients. The patients of ST fall by more than 50% and H-FABP decreased to normal status, clinical myocardial injury lighter, reperfusion effect was better.