氧气雾化吸入小牛血清去蛋白提取物治疗化疗相关口腔黏膜炎的疗效观察

Clinical efficacy of oxygen aerosol inhalation deproteinized hemoderivative of calf blood in chemotherapy-induced oral mucositis

目的 探讨氧气雾化吸入小牛血清去蛋白提取物治疗化疗所致口腔黏膜炎的临床价值.方法 将40例接受化疗后出现口腔黏膜炎的患者随机分为观察组和对照组各20例,观察组采用3％碳酸氢钠溶液漱口基础上加用氧气雾化吸入小牛血清去蛋白提取物治疗,对照组使用3％碳酸氢钠溶液漱口.连续治疗5天,观察两组口腔溃疡治疗效果差异.结果 观察组总有效率为95％,对照组为70％,两组总有效率比较差异有统计学意义（P＜0.05）;观察组的口腔粘膜炎愈合需要时间较对照组缩短.结论 氧气雾化吸入小牛血清去蛋白提取物有利于肿瘤患者化疗相关性口腔黏膜炎恢复,安全性好,有临床应用价值.

Objective To investigate the clinical efficacy of oxygen aerosol inhalation deproteinized hemoderivative of calf blood in the treatment of chemotherapy-induced oral mucositis.Methods 40 cases of chemothcrapy-induced oral mucositis were randomly divided into observation group and control group,20 cases in each group.Both groups were given 3% sodium bicarbonate solution gargle,observation group was given oxygen aerosol inhalation deproteinized hemoderivative of calf blood on the basis.The curative effect was observed after 5 days＇ treatment.Results The total effective rate of observation group was 95%,that of control group was 70%,with statistically significant difference between two groups （P〈0.05）.The healing time of oral mucositis of observation group was shorter than that of control group （P〈0.05）.Conclusion The method of oxygen aerosol inhalation deproteinized hemoderivative of calf blood has a significant therapeutic effect on chemotherapy-induced oral mucositis in cancer patients,and it is safe,worthy of clinical application.