肝细胞癌和胆管细胞癌动物模型构建的新进展

Advance in the animal models of hepatocellular carcinoma and cholangiocarcinoma

动物模型是肿瘤研究过程中的有力工具,它为研究肿瘤发生发展的病因、病理生理及微环境提供良好条件,新治疗方法的疗效也可以通过肿瘤模型在临床前期得到验证。肝细胞癌和胆管细胞癌作为原发肝癌的两个亚型,在动物模型的构建中既有区别又有联系,现就这两类动物模型构建最新进展进行总结分析。

Animal model is a fundamental and useful tool in tumor research. As a substitute,it provides a good condition for the researching of etiology, pathology, physiology and micro environment in tumor progress. The efficacy of new treatments can also be verified by tumor model preclinically.Hepatocellular carcinoma and cholangiocarcinoma confirmed as two subtypes of primary liver cancer,the methods for constructing animal models have both similarities and differences which will be summary analyzed in this article.