慢性肝病患者凝血功能检测结果分析

Analysis of coagulation function test results in patients with chronic liver disease

目的探讨慢性肝病患者凝血功能的变化。方法对97例各型慢性肝炎患者进行血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)测定并与健康对照组进行比较。结果慢性肝炎及肝硬化患者PT、APTT、TT显著延长(P<0.01),FIB含量明显降低(P<0.01)。慢性酒精性肝病及药物性肝病患者PT、APTT显著延长(P<0.01),其TT和FIB含量差异无统计学意义(P>0.05)。结论进行凝血功能检查对监测慢性肝病患者出血倾向及指导临床治疗和估计预后具有重要的参考价值。

Objective To investigate the changes of coagulation function in patients with chronic liver disease. Methods Total of 97 cases with various types of chronic hepatitis measure prothrombin time（PT）, activated partial thromboplastin time（APTT）, thrombin time（TT）, fibrinogen（FIB） with the healthy control group for comparison. Results Chronic hepatitis, cirrhosis patients with PT, APTT, TT were significantly prolonged（P〈0.01）, the content of FIB was decreased（P〈0.01）, chronic alcoholic liver disease, drug induced liver injury in patients with PT, APTT significantly prolonged（P〈0.01）, there were no significant difference between TT and FIB content（P〈0.05）. Conclusions Coagulation tests have a high reference value to monitor patients with bleeding tendency, guide clinical treatment and evaluate prognosis.