心痛方治疗不稳定型心绞痛的临床疗效观察及其对黏附分子的影响

Clinical Curative Effect of Xintong Decoction on Patients with Unstable Angina Pectoris and Its Impact on Adhesion Molecule

目的观察心痛方治疗不稳定型心绞痛(UA)痰瘀互结气滞证的临床疗效,并从抑制黏附分子(ICAM-1、VCAM-1)的表达来探讨心痛方的疗效机制。方法将80例UA患者按随机原则分为治疗组(心痛方加西医常规治疗)和对照组(西医常规治疗),每组40例,疗程均为4周,进行临床疗效观察,包括治疗前后中医证候改变、心绞痛发作的程度、硝酸甘油用量、心电图变化等;并检测UA患者治疗前后细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)水平。结果治疗组UA患者的临床证候、心电图总有效率均明显优于对照组(P<0.01),治疗组对缓解心绞痛、硝酸甘油停减率、改善中医证候的效果以及降低ICAM-1、VCAM-1水平明显优于对照组(P<0.01)。结论心痛方治疗不稳定型心绞痛痰瘀互结气滞证有良好的临床疗效,能降低ICAM-1及VCAM-1水平,提示该方能干预黏附分子,从而抑制炎症反应。

Objective： To observe the clinical curative effect of Xintong Decoction in treating unstable angina from the inhibition of adhesion molecule expression,and detect into its intervention mechanism on UA. Methods：Patients were randomly divided into the treatment group with Xintong Decoction plus routine western medicine and the control group with routine western medicine. The courses were 4 weeks. Some indicators were observed before and after treatment including clinical curative effect of syndromes,angina pectoris,nitroglycerin consumption changes,ICAM-1 and VCAM-1. Results： The clinical syndrome and the total effective rate in the treatment were superior to those in the control group（P〈0.01）. In the treatment group,TCM syndrome score,angina pectoris,nitroglycerin discontinue rate,ECG,ICAM-1,VCAM-1 level were significantly better than those in the control group. Conclusion： Xintong Decoction has good curative effect in treating UA.It can reduce level of ICAM-1and VCAM-1 in patients with UA which could intervene the adhesion molecules to inhibit the inflammatory response.