独活寄生合剂联合心理干预对膝骨关节炎患者负性情绪的影响

Effects of Duhuo Jisheng Mixture combined with Psychological Interventions on Negative Emotion of Patients with Knee-osteoarthritis

目的观察独活寄生合剂联合心理干预对膝骨关节炎患者负性情绪的影响。方法 100例患者随机分成对照组、干预组各50例。对照组予以独活寄生合剂作为基础治疗,干预组在对照组基础上联合心理干预治疗。治疗4周。观察视觉模拟量表(VAS)、骨关节炎指数(WOMAC)评分、抑郁自评量表(SDS)、焦虑自评量表(SAS)在治疗前后的变化。结果两组治疗前VAS评分、WOMAC评分差异不大(P>0.05)。两组治疗后VAS评分、WOMAC评分均较治疗前有改善(P<0.05),且干预组疗效优于对照组(均P<0.05);两组SDS总分、SAS总分随治疗时间呈现逐渐下降趋势,且干预组较对照组下降明显(P<0.05)。全部受试对象治疗前后均未见明显肝肾功能损害及血液学异常。结论独活寄生合剂联合心理干预可以减轻膝骨关节炎患者临床症状,改善患者生存质量和负性情绪。

Objective： To investigate effects of Duhuo Jisheng Mixture combined with psychological interventions on negative emotion of patients with knee-osteoarthritis. Methods： 100 knee-osteoarthritis patients were randomly divided into two groups with 50 cases in each group. The control group was used Duhuo Jisheng Mixture 3times a day. And intervention group,besides Duhuo Jisheng Mixture,was added psychological interventions. After4 weeks,VAS,WOMAC,self-rating depression scale（SDS） and self-rating anxiety scale（SAS） of the two groups were determined and compared between prior and post treatment. Results： There were significant differences in VAS and WOMAC scores between before and after treatment in both groups（P〈0.05）,so as that between the two groups（P〈0.05）. Compared with the control group,the SDS and SAS scores of the two groups were decreased gradually after the treatment（P〈0.05）,while there was remarkable descending of SDS and SAS scores in patients of psychological intervention group（P〈0.05）. Conclusion： Duhuo Jisheng Mixture combined with psychological interventions can improve clinical efficacy and ameliorate the depression of knee osteoarthritis patients.The quality of life of knee osteoarthritis patients can be improved by psychological intervention.