灯盏细辛注射液对ARDS炎性因子及凝血机制的影响

Effect of Erigeron Breviscapus Injection on Inflammatory Factors and Clotting Mechanism in ARDS Patients

目的观察灯盏细辛注射液对中-重度急性呼吸窘迫综合征(ARDS)患者炎症因子及凝血功能的影响,并评价其临床效果。方法 30例患者随机分成对照组和灯盏细辛组。两组均给予常规治疗,灯盏细辛组在常规治疗基础上每天加用灯盏细辛注射液30 m L静脉滴注,共15 d。测定两组患者治疗前后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及纤维蛋白原(FIB)、纤溶酶原活性(PLG)、假性血友病因子(vWF),观察氧和指数(Pa O2/Fi O2),SOFA评分的变化,观察机械通气时间、住ICU时间、住院时间及28 d死亡率。结果与对照组比较,灯盏细辛组治疗后15d CRP水平下降(P<0.05),FIB下降(P<0.01),v WF下降(P<0.05),PLG升高(P<0.05),氧和指数升高(P<0.05),SOFA评分降低(P<0.05)。机械通气时间、住ICU时间及住院时间缩短(P<0.05),28 d死亡率差异无显著性。结论灯盏细辛能够减轻ARDS的炎症反应,改善凝血功能,改善氧合,降低器官功能障碍的发生。

Objective： To observe the effect of erigeron breviscapus injection on inflammatory reaction and blood clotting in patients with acute respiratory distress syndrome（ARDS） and evaluate its clinical result. Methods： 30 ARDS patients were randomly divided into the control group（group C） and the erigeron breviscapus injection group（group E）. Group E receive erigeron breviscapus injection 30 m L daily for 15 days on the basis of routine therapies in 2 groups. Changes prior treatment and up to 15 day will be recorded including C-reactive protein（CRP）,TNF-α,IL-6,fibrinogen（FIB）,plasminogen（PLG）,von Willebrand（vWF）,oxygenation index（PaO2/FiO2）and sequential organ failure assessment score（SOFA）. Also,some indicators were observed such as the mechanical ventilation time,the length of ICU,the hospital stay and the 28 days time mortality. Results： Compared with group C,the CRP,the TNF-α,the IL-6,Fib and v WF were decreased（P〈0.05 or P〈0.01）. PLG was increased（P〈0.05）. SOFA score was decreased（P〈0.05） and Oxygenation index was increased（P〈0.05） in Group E up to15 days. Meanwhile,the Mechanical ventilation time and the ICU and hospital stay time were reduced（P〈0.05）.However,there was no significant difference in mortality between the two groups. Conclusion： Erigeron breviscapus injection can relieve inflammatory reaction to improve function of blood clotting and oxygenation. Meanwhile,it can reduce the occurrence of organ dysfunction of ARDS.