住院科室注射抗菌药使用强度的分析

Analysis of the Use Intensity of Injection of Antibacterial Drug in Inpatient Departments

目的了解该院住院科室注射抗菌药使用情况,探讨临床合理用药。方法收集该院2014年6月1日—30日的8个住院科室应用注射抗菌药有关数据,以限定日剂量(DDD)为单位,计算不同科室抗菌药用药频度(DDDs)和药物利用指数(DUI)并进行分析。结果住院科室注射抗菌药涉及6类21个品种,统属β-内酰胺类的青霉素类、头孢菌素类及非典型β-内酰胺类抗菌药占抗菌药物使用总强度的94.5%,而青霉素类和头孢菌素类复合制剂占抗菌药物使用总强度的41.4%,DDDs排序前5位依次为美洛西林钠舒巴坦钠、头孢地嗪钠、头孢哌酮钠他唑巴坦钠、头孢甲肟和磺苄西林钠;DDD排序前10位的抗菌药中有5个品种DUI值等于或接近2。结论个别住院科室可能存在用药集中、过度用药及单次用药剂量偏大的问题。

Objective To investigate the use intensity of injection of antibacterial drug in inpatient departments and study the ra- tional clinical drug use. Methods With defined daily dose （DDD） as the unit, the data of injection of antibacterial drug used in 8 inpatient departments of our hospital were collected to calculate and analyze the intensity of Digital Data Display System （DDDs） and drug utilization index （DUI）. Results The injection of antibacterial drug in inpatient departments included 6 kinds 21 species, penicillin and cephalosporin belonging to Beta lactam and atypical beta lactam antimicrobials accounted for 94.5% of total antimi- crobial usage intensity, while the penicillin and cephalosporin compound preparation accounted for 41.4%. The first 5 drugs of DDDs were Mezlocillin Sodium and Sulbactam Sodium, Cefodizime Sodium, Cefoperazone Sodium and Tazobactam Sodium, Cef- menoxime and Sulbenicillin Sodium. The DUI of 5 species among the top 10 antibiotics of DDDs was equal or close to 2. Con- clusion Drug concentration, over-medication and an excessive big single dosage were the problems existing in individual inpatient departments.