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临床标志物在帕金森病早期诊断中的作用 被引量：5

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摘要 除运动症状外,非运动症状（NMS）在帕金森病各期均可出现,有研究表明一些NMS如抑郁、便秘、嗅觉障碍、快速眼动期睡眠行为障碍（RBD）等可能在运动症状出现之前就已存在,这一时期可历时5 ～ 20年[1-2]。研究帕金森病亚临床期的种种异常,从而找到早期诊断及防治帕金森病的靶点是目前国内外研究的热点。我们就NMS作为临床标志物在帕金森病早期诊断中的作用作一系统综述。 一、睡眠障碍 约96％的帕金森病患者存在睡眠障碍。与对照组相比，新诊断的帕金森病患者白天瞌睡明显增加，帕金森病诊断前5年，失眠发病率也明显提高[3-4]。除此之外，RBD是帕金森病睡眠障碍中最主要的潜在临床标志物。
作者 康文岩 陈生弟
机构地区 上海交通大学医学院附属瑞金医院神经科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2015年第6期539-542,共4页 Chinese Journal of Neurology
基金 国家重点基础研究“973”计划资助项目（2011CB504104） 国家自然科学基金重点项目（81430022）
关键词 帕金森病诊断 临床标志物 早期诊断 快速眼动期睡眠行为障碍 非运动症状 睡眠障碍 嗅觉障碍 亚临床期
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献46

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共引文献9

同被引文献92

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引证文献5

二级引证文献20

中华神经科杂志
2015年 第6期

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