降钙素原能否有效区分脓毒症与非感染性全身炎症反应综合征

Can procalcitonin differentiate sepsis from noninfectious systemic inflammatory response syndrome？

脓毒症起病急、进展快、病死率高，其临床表现与非感染性全身炎症反应综合征非常相似，两者鉴别困难，往往造成抗生素的滥用或迟用。降钙素原是目前公认的脓毒症的生物标志物，但其也有局限性。在鉴别脓毒症与非感染性全身炎症反应综合征时，要紧密结合临床特征综合判断，并动态监测。（中华检验医学杂志，2015，38：364-366）

Sepsis is featured with acute onset, rapid progress and high mortality.Because its clinical manifestations is very similar to noninfectious systemic inflammatory response syndrome, it is difficult to diffferentiate the two diseases, which results in delayed use or abuse of anti-infective drugs.Procalcitonin is widely recognized as a sepsis biomarker, but it has its limits.Procalcitonin must be interpreted cautiously, in conjunction with the clinical picture.Dynamic monitoring of procalcitonin can give clinicians more help.