降钙素原清除率对脓毒症患者预后评估的价值

The prognostic value of serum procalcitonin clearance on patients with sepsis

目的探讨降钙素原(PCT)清除率对脓毒症患者预后的影响。方法 82例脓毒症患者在入院后第1、3、5、7 d测定PCT,根据预后分为死亡组(n=23)和存活组(n=59),比较两组PCT清除率。结果两组基础疾病构成比例类似,死亡组合并有多脏器功能衰竭的比例较高。第3、5、7 d PCT清除率(PCTc-3、PCTc-5、PCTc-7)存活组明显高于死亡组,差异有统计学意义(P<0.05);受试者工作(ROC)曲线分析提示PCTc-7的曲线下面积(AUC)为0.892明显高于PCTc-3、PCTc-5。结论 PCTc-7可作为评估脓毒症预后的重要指标,其截值≥40%可作为预后有利的预测指标。

Abstarct：Objective To explore procalcitonin（PCT）clearance for the prognosis of septic patients. Methods PCT were tested on day 1, 3, 5 and 7 in 82 patients with sepsis which were divided into survival group（n=59）and dead group（n=23）according to prognosis. PCT clearance were compare between the two groups. Results Compared with dead group,PCT clearance on day 3,5 and 7 were higher in survival group than in control group（P〈0.05）. The AUC of PCT clearance on day 7 was 0.892 under the ROC curve, which was bigger than PCT clearance on day 3 and 5. Conclusion PCT clearance on day can predict the prognosis of patients with sepsis; a 40% or more than 40% clearance indicates better prognosis.