牙周基础治疗对消化性溃疡病患者治疗效果的影响

Influence of initial periodontal therapy on peptic ulcer

目的探讨牙周基础治疗对消化性溃疡病内科治疗的影响。方法 50例消化性溃疡病患者分为观察组25例和对照组25例,2组患者均接受正规抗消化性溃疡内科治疗,观察组接受牙周基础治疗,对照组未接受任何牙周治疗。比较2组牙周指标、临床疗效及幽门螺杆菌(Helicobacter pylori,HP)根除率。结果治疗后和随访6个月时观察组菌斑指数(plague index,PI)(1.24±0.65、1.30±0.57)、牙龈指数(gingival index,GI)(1.68±0.56、1.72±0.61)、牙周袋探诊深度(probing depth,PD)(2.35±0.90、2.40±0.87)、临床附着丧失(clinical attachment loss,CAL)(2.50±0.56、2.62±0.68)及探针出血指数(bleading on probing,BOP)(25.00±12.00、28.00±10.00)较治疗前(PI为1.89±0.68、GI为2.23±0.65、PD为3.27±1.27、CAL为3.18±0.44、BOP为41.00±14.00)和对照组(PI为1.92±0.70、1.96±0.67;GI为2.23±0.65、2.24±0.59;PD为3.30±1.30、3.38±1.02;CAL为3.20±0.50、3.28±0.61;BOP为40.00±13.00、43.00±17.00)明显改善(P<0.05);治疗后观察组有效率(92%)高于对照组(60%)(P<0.05),HP根除率(92%)与对照组(88%)比较差异无统计学意义(P>0.05);随访6个月时对照组临床症状再次出现率(48%)和HP再感染率(48%)高于观察组(12%、12%)(P<0.05)。结论消化性溃疡病患者应控制牙菌斑,通过牙周基础治疗可降低HP再感染率、改善消化性溃疡患者不适症状。

Objective To study the influence of initial periodontal therapy on peptic ulcer.Methods Fifty patients with peptic ulcer were divided into observation group and control group,with 25 patients in each group.Control group received regular anti-peptic ulcer treatment,besides which observation group received initial periodontal treatment. The periodontal index,clinical therapeutic effect and Helicobacter pylori（HP）eradication rate were compared between two groups.Results The plaque indexes（1.24±0.65,1.30±0.57）,gingival indexes（1.68±0.56,1.72±0.61）,probing depth indexes（2.35±0.90,2.40±0.87）,clinical attachment loss indexes（2.50±0.56,2.62±0.68）and the indexes of bleeding on probing（25.00±12.00,28.00±10.00）after treatment and after 6-month follow-up survey were lower than those before treatment in observation group（1.89±0.68,2.23±0.65,3.27±1.27,3.18±0.44,41.00±14.00）and control group（1.92±0.70,1.96±0.67;2.23±0.65,2.24±0.59;3.30±1.30,3.38±1.02;3.20±0.50,3.28±0.61;40.00±13.00,43.00±17.00）（p〈0.05）.The clinical effective rate was higher in observation group（92%）than that in control group（60%）after treatment（p〈0.05）.The HP eradication rate showed no significant difference between observation group（92%）and control group（88%）after treatment（p〈0.05）.The recurrence rate of the clinical symptoms and HP re-infection rate（48%,48%）were higher in control group than those in observation group（12%,12%）after 6-month follow-up survey（p〈0.05）.Conclusion The dental plaque should be cleared in the patients with peptic ulcer.The initial periodontal therapy can reduce the HP re-infection rate and improve the symptoms of peptic ulcer.