2型糖尿病患者甲状腺激素水平与血管并发症的相关性

Correlation between thyroid hormone level and vascular complication in patients with type 2 diabetes mellitus

目的探讨2型糖尿病患者甲状腺激素水平与血管并发症的关系。方法将521例2型糖尿病患者分为2组,甲状腺功能正常456例为正常组,合并亚临床甲状腺功能减退65例为甲减组。根据2组辅助检查及各项实验室检查指标,比较2组心血管疾病、脑血管疾病、糖尿病肾病、视网膜病变、外周血管病变发生率。结果 2组年龄、病程、空腹血糖水平比较差异无统计学意义(P>0.05),甲减组心血管疾病(72.3%)、脑血管疾病(15.4%)、糖尿病肾病(63.1%)、视网膜病变(43.1%)、外周动脉病变(47.8%)发生率高于正常组(61.8%、13.8%、43.0%、25.9%、31.8%),2组比较差异有统计学意义(P<0.05)。结论定期检查糖尿病患者甲状腺功能并及时治疗甲状腺功能减退,有助于降低糖尿病血管并发症的发生。

Objective To explore the correlation between thyroid hormone levels and vascular complications in patients with type 2diabetes mellitus（T2DM）.Methods A total of 521 patients with T2 DM were divided into normal thyroid function group（n=456）and subclinical hypothyroidism group（n=65）according to the thyroid function.The laboratory indexes were detected to analyze the incidences of cardiovascular disease,cerebral disease,diabetic nephropathy,retinopathy and peripheral vascular disease.Results There were no significant differences in the age,disease course and fasting plasma glucose between two groups（p〈0.05）.The incidences of cardiovascular disease,cerebrovascular disease,diabetic nephropathy,retinopathy and peripheral vascular disease were significantly higher in subclinical hypothyroidism group（72.3%,15.4%,63.1%,43.1%,47.8%）than those in normal thyroid function group（61.8%,13.8%,43.0%,25.9%,31.8%）（p〈0.05）.Conclusion Regular detection of thyroid function and prompt treatment of subclinical hypothyroidism contribute to the decrease of incidence of vascular complications.