宫颈癌患者根治术后院内感染的细菌学培养及抗菌药物应用

Cultivation of bacteriology and antimicrobial agents application in cervical cancer patients after nosocomial infection

目的:探讨宫颈癌患者根治术后院内感染的细菌培养病原菌种类及其对抗菌药物的耐药性。方法:分析2003年3月-2013年5月10年间治疗的110例行宫颈癌根治术患者资料,观察院内感染及合理使用抗菌药物状况。结果:在110例宫颈癌根治术患者中,28例感染泌尿系统疾病,占25.5%;尿潴留感染者37例,占33.6%;其他并发症感染者为5例,占4.5%。分离出99株病原菌,其中革兰阳性菌34株,占34.3%;革兰阴性菌50株,占50.5%;其他菌种15株,占15.2%。感染的病原菌以粪肠球菌、大肠埃希菌、铜绿假单胞菌以及真菌为主。大肠埃希菌对大部分药物耐药性强,其次是铜绿假单胞菌对抗菌药物耐药性强。所有病原菌对庆大霉素耐药性强,对去甲万古霉素耐药性最低,尤其是革兰阴性菌。结论:宫颈癌根治术患者易发生院内感染,应正确掌握病原菌的感染分布状况,合理使用抗菌药物。

Objective：To discuss cervical cancer Patients after bacterial culture radical nosocomial Pathogens and its resistance on antimicrobial agents. Methods：Data of 110 Post radical hysterectomy Patients in our hosPital from March 2003 to May 2013,was analyzed. Results：In 110 cases,28 cases got urinary tract infection（UTI）（25. 5%）, 13 cases was infected lymPhatic swollen bursa（11. 8%）,5 cases（4. 5%）other comPlications of infection. 99 strains of Pathogenic bacteria were isolated,including 34 gram Positive strains（34. 3%）,and 50 gram negative strains （50. 5%）. The number of other strains was 15（15. 2%）. Pathogen was mainly infected by Enterococcus faecalis, Escherichia coli,Pseudomonas aeruginosa and fungi. Escherichia coli was strongly resistant to the vast majority of drug,and Pseudomonas aeruginosa was suscePtive to antimicrobial agents. All Pathogens was sensitive to roxithromycin and lowestly resistent to cefoxitin. Conclusion：Because of liability to nosocomial infections in radical hysterectomy Pa-tients,we should correctly grasP the distribution of Pathogenic bacteria and rationally use the antimicrobial drugs.