C反应蛋白联合4项肿瘤标志物检测肺癌的临床研究

Significance of 4 tumor markers and C-reactive for lung cancer

目的:探讨CRP联合4项肿瘤标志物检测肺癌的临床价值。方法:随机选取我院2011年5月-2014年5月收治的50例肺癌患者、40例良性肺部疾病患者和30例健康志愿者为研究对象。取外周血检测CRP、CEA、CA125、CYFRA21-1、NSE含量。结果:肺癌组和肺良性疾病组CRP和CA125检测结果显著高于健康组,肺癌组CEA、NSE和CYFRA21-1水平显著高于肺良性疾病组和健康组,肺癌组CRP值显著低于肺良性疾病组,差异具有统计学意义(P<0.05)。肺癌不同病理组织分型中显示腺癌组CEA和CA125水平显著高于小细胞肺癌组和鳞癌组,小细胞肺癌组血清NSE水平显著高于腺癌组和鳞癌组,鳞癌组CYFRA21-1水平显著高于小细胞肺癌组,鳞癌组CA125水平显著低于小细胞肺癌组和腺癌组,差异具有统计学意义(P均<0.05)。患者血清CRP、CEA、CA125、NSE、CYFRA21-1单项检测敏感度均较低,特异性稍高,联合检测结果显示敏感度显著升高,但特异性有所下降。结论:C反应蛋白联合4项肿瘤标志物检测可以提高检测的敏感性,增高阳性检出率。

Objective：To investigate the C-reactive protein （CRP） combined with four tumor markers in lung cancer diagnosis.Methods：Randomly selected 50 cases of lung cancer,40 patients with benign lung disease and 30 healthy people,to detect CRP,CEA,CA125,CYFRA21-1,NSE.Results：In lung cancer patients and patients with benign lung disease CRP and CA125 were significantly higher than the healthy group.In lung cancer CEA,NSE and CYFRA21-1 were significantly higher than benign lung disease and healthy group.In lung cancer group CRP was significantly less than benign lung disease group,the difference was statistically significant （P ＜ 0.05）.For serum CRP,CEA,CA125,NSE,CYFRA21 single detection sensitivity were low,specificity higher.Combined test results showed a significant increase in sensitivity,but the specificity decreased.Conclusion：C-reactive protein combined four tumor markers can improve the sensitivity with higher positive rate.