经尿道膀胱黏膜与膀胱颈联合电切配合术后吡柔比星灌注治疗女性腺性膀胱炎临床研究

Effect of transurethral bladder and bladder neck joint THP transurethral surgery on female glandular cystitis

目的:探讨经尿道膀胱黏膜与膀胱颈联合电切配合术后吡柔比星灌注治疗女性腺性膀胱炎的临床效果。方法:选取2009年-2013年在我院接受治疗的腺性膀胱炎女性患者120例。随机分为观察组与对照组,每组60例。两组患者均给予经尿道膀胱黏膜与膀胱颈联合电切术。在次基础上,观察组给予术后吡柔比星进行治疗。观察两组治疗效果、尿动力学指标、不良反应,并随访复发结果。结果:观察组治疗显效29例,有效26例,无效5例,治疗有效率为91.67%;对照组治疗显效21例,有效25例,无效14例,治疗有效率为76.67%。观察组治疗有效率明显高于对照组(P<0.05)。观察组最大尿流率为(24.32±6.31)ml/s,平均尿流率为(12.67±5.98)ml/s,最大尿道压为(7.21±1.72)k Pa;对照组最大尿流率为(17.87±8.75)ml/s,平均尿流率为(7.99±5.43)ml/s,最大尿道压为(10.98±3.01)k Pa。观察组膀胱刺激征7例,骨髓抑制0例,肾功能损害1例,皮疹1例,尿道狭窄1例,不良反应发生率为16.67%(10/60);对照组膀胱刺激征12例,骨髓抑制3例,肾功能损害2例,皮疹3例,尿道狭窄2例,不良反应发生率为36.67%(22/60)。对两组患者随访,随访率100%。观察组随访时间为(14.34±3.43)个月,对照组随访时间为(14.04±3.41)个月,两组随访时间无显著差异(P>0.05)。观察组复发率为15.00%,对照组复发率为31.67%。结论:经尿道膀胱黏膜与膀胱颈联合电切配合术后吡柔比星灌注治疗女性腺性膀胱炎治疗效果显著,且复发率低,临床上值得推广。

Objective：To analyze the effect of the bladder through the urethra and bladder neck mucosa combined with transurethral surgery Pirarubicin infusion on female glandular cystitis.Methods：All 120 cases of women cystitis with glandular were randomly divided into observation group and control group,60 cases in each.Two groups of patients were treated with transurethral resection of the bladder mucosa and bladder neck joint resection.Observation group was treated by Pirarubicin treatment.Results：In treatment group cured 29 cases,effective 26 cases,ineffective five cases,the effective rate was 91.67％;In control group therapy cured 21 cases,effective 25 cases,ineffective in 14 cases,the treatment rate was 76.67％ （P ＜0.05）.The maximum flow rate of the observation group was （24.32 ± 6.31） ml/s,average flow rate （12.67-± 5.98） ml/s,maximum urethral pressure （7.21 ± 1.72） kPa;maximum flow rate of the control group （17.87 ±-8.75） ml/s,average flow rate （7.99-± 5.43） mL/s,maximum urethral pressure （10.98 ± 3.01） kPa.In observation group there were seven cases of bladder irritation,bone marrow suppression 0,one case of renal impairment,rash one case,one case of urethral stricture,adverse reactions was 16.67％ （10/60）,in the control group 12 cases of bladder irritation,bone marrow inhibition of 3 cases,2 cases of renal dysfunction,rashes three cases,two cases of urethral stricture,adverse reaction rate was 36.67％ （22/60）.Recurrence rate was 15.00％ in the observation group,the control group,the recurrence rate was 31.67％.Conclusion：Transurethral bladder and bladder neck surgery combined with transurethral Pirarubicin perfusion treatment on female glandular cystitis treatment is effective.