BP1基因在结肠癌组织中的表达

Clinical significance of BP1 gene expression in colonic carcinoma tissues

目的:检测BP1基因在结肠癌组织中的表达,探讨其与结肠癌临床病理因素的关系。方法:利用免疫组织化学SP法检测68例结肠癌及相应的结肠正常组织中BP1蛋白的表达情况,并分析其与病人年龄、性别、肿瘤分化程度等临床病理特征之间的相关性。结果:免疫组化SP法检测示:结肠癌组织中BP1基因蛋白的表达水平明显高于结肠正常组织(P<0.05),BP1的表达与肿瘤的分化程度及TNM分期有关(P<0.05)。结论:BP1基因在结肠癌组织中的表达显著上调;BP1基因的表达与肿瘤分化程度、TNM分期有关,而与年龄、性别、肿瘤大小、组织类型无关。

Objective：To identify the expression of BP1 gene and its relationships with clinical features in colonic carcinoma tissues.Methods：Immunohistochemistry was employed for detecting BP1 gene expression in 68 colonic carcinoma tissues and 68 normal colonic tissues.Results：Significant difference of BP1 gene expression was found between the colonic carcinoma tissues and normal colonic tissues by using immunohistochemistry（P ＜ 0.05）.There was significant relationship between expression of BP1 gene with tissues of differentiation and TNM stage.Conclusion：BP1 gene expression is up-regulated in human colonic carcinoma tissues in related to differentiation and TNM stage but not to patient age,sex and tumor size,pathological type.