基于唾液生物信息诊断胰腺癌的现状分析

Diagnosis of pancreatic cancer based on biological information of saliva: an analysis of current status

胰腺癌是消化系统常见的恶性肿瘤之一,目前仍缺乏有效的早期诊断手段。唾液是一种口腔腺体分泌液和黏膜渗出液等构成的混合性生物流体,当机体存在病变时,其所含的微生物、蛋白质及核酸等生物信息也随之发生改变,因此可作为疾病诊断的媒介之一。通过总结唾液诊断学研究现状及其优点,分析当前利用唾液诊断胰腺癌已取得的研究成果,认为利用唾液生物信息诊断胰腺癌拥有广阔的应用前景。

Pancreatic cancer is one of common malignant tumors in the digestive system.There is still no effective means for the early diag-nosis of pancreatic cancer.As a mixture of oral gland secretion and oral mucosal transudate,saliva contains abundant biological information including microorganisms,proteins,and nucleic acids,which will change when the disease occurs.So saliva can be used for the early diag-nosis of pancreatic cancer.Through summarizing and analyzing the current studies and advantages of its application for early diagnosis,this article suggests that saliva bioinformatics holds promise for the application in the early diagnosis of pancreatic cancer.