补体在儿童免疫和/或炎症性肾脏疾病中的新认识

New understanding of complement in childhood immune and/or inflammatory renal diseases

补体系统是人体固有免疫不可或缺的成分,除参与机体防御反应和维持内环境稳定外,补体系统还和多种肾脏疾病的发生、发展相关。近期研究证实组织与免疫细胞来源的补体均可介导局部组织的炎症反应。补体系统不仅是连接固有免疫和获得性免疫的桥梁,也是介导组织损伤的致病性体液和细胞免疫的桥梁。越来越多的证据表明,补体系统功能缺陷或异常活化在肾脏自身免疫疾病、缺血再灌注损伤、移植排斥反应及透析相关疾病中均起着炎性介导作用。针对这一系列肾脏免疫和/或炎症性疾病,补体作用的靶向性药物可能会改善其疗效及预后,提高患者生活质量。

The complement system, the chief component of innate immunity, is not only required for host defense against pathogens and homeostasis, but also related to the pathogenesis and development of various kidney diseases. Recent study has shown that tissue-derived complement and immune cell-derived complement can each mediate local inflammation. The complement system acts as a bridge between innate and adaptive immunity. Furthermore it＇s also a functional bridge between pathogenic humoral and cellular immune responses in an array of kidney diseases. Increasing evidence links inappropriate complement activation and deficiencies of complement proteins to the pathogenesis of kidney autoimmune disease, ischemia-reperfusion injury, transplant rejection and complications in hemodialysis. The development of pharmacologic agents that target complement in patients with this assortment of immune and/or inflammatory kidney diseases has the potential to abrogate disease progression and improve patient health.