干扰素调节因子6和视黄酸受体与非综合性唇腭裂的关系

The Expression of IRF6,RARA in Tissues of the Patients with NSCL/P

目的:探讨干扰素调节因子6(IRF6)和视黄酸受体(RARA)与非综合性唇腭裂(NSCL/P)的关系。方法:35例NSCL/P患儿唇腭裂裂缘皮肤黏膜组织标本作为病例组,15例正常儿童的口唇部皮肤黏膜组织作为对照组,免疫组织化学法检测两组所取组织标本IRF6、RARA的表达。结果:IRF6在唇腭裂裂缘组织中的表达高于对照组,差异有统计学意义(P<0.05);RARA在唇腭裂裂缘组织中的表达明显高于正常对照组,差异有统计学意义(P<0.05)。结论:IRF6和RARA在唇腭裂裂缘组织中的表达增高,可能与NSCL/P的发生有关。

Objective： To investigate the correlation of interferon regulatory factors 6（ IRF6） and retinoic acid receptor（ RARA） with NSCL / P（ non syndrome cleft lip and / or cleft palate）. Methods： 35 cleft mucous membrane tissue samples were collected from the NSCLP children patients（ experimental group）; 15 mucous membrane tissue from healthy children（ control group）. Adopting SP immunohistochemistry method to examine the expression of IRF6 and RARA in groups. Results： IRF6 expression in cleft mucous membrane tissue was higher than that of control group,differences were statistically significant（ P 0. 05）; RARA expression in cleft mucous membrane tissue was higher than that of control group,differences were statistically significant（ P 0. 05）. Conclusion： The increased expression of IRF6 and RARA in cleft mucous membrane tissue gene may lead to the occurrence of NSCL / P.