乳腺癌组织中碘化钠同向转运蛋白的表达及其诱导与乳腺癌放射碘治疗

The sodium iodide symporter: expression and induction in breast cancer and breast cancer radioiodine therapy

碘化钠同向转运蛋白(NIS)是一种调控甲状腺滤泡细胞碘吸收的跨膜糖蛋白。NIS调控甲状腺细胞碘吸收是甲状腺及其转移癌放射碘治疗的基础。然而研究证实,NIS除表达于哺乳期乳腺细胞上外,还表达于多数乳腺癌细胞,提示放射碘治疗也可能成为乳腺癌一种可行的治疗方法,尤其是对三阴性乳腺癌及乳腺癌脑转移患者。然而,乳腺癌细胞表面NIS蛋白表达通常都较低,且只有表达于细胞表面的NIS方具备放射碘吸收能力。因此揭示不同水平上NIS表达的调控机制就显得格外重要。本文就NIS在乳腺癌中的表达及其诱导与乳腺癌放射碘治疗的研究进展作一综述。

The sodium iodide symporter（ NIS） is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. NIS？mediated iodide uptake in thyroid cells is the basis for treatment of differentiated thyroid carcinomas and their me？tastases. Furthermore, NIS is expressed in many human breast tumors, suggesting that NIS？mediated radionuclide uptake may be used for the targeted therapy of breast cancer. However, functional cell surface NIS expression is often low in breast cancer, making it impor？tant to uncover signaling pathways that modulate NIS expression at multiple levels, from gene transcription to posttranslational process？ing and cell surface trafficking. In this review, we summarized the research progress of the presence, relevance and regulation of NIS in breast cancer. The clinical significance of NIS in breast cancer radioiodine therapy will also be discussed.