山茱萸提取物改善脊髓损伤小鼠骨质疏松的研究（英文）

Extract of Cornus officinalis SIEB ameliorates osteoporosis in Spinal Cord-Injured Rats

目的观察山茱萸的提取物对脊髓损伤大鼠的骨质疏松的治疗作用。方法 40只Wistar雄性大鼠分成四组:标准对照组、脊髓损伤组、脊髓损伤高剂量提取物治疗组、脊髓损伤低剂量提取物治疗组。除标准对照组外,建立脊髓损伤引起的骨质疏松大鼠模型,然后进行相关生物化学、骨密度及形态的分析和比较。结果与标准对照组相比,脊髓损伤组的大鼠显示骨量、生物化学指标和形态学参数的显著下降。山茱萸提取物高剂量组治疗大鼠胫骨骨干内、外部区域骨质疏松显示剂量依赖性。结论山茱萸提取物治疗可能通过刺激成骨细胞引骨组织反应,从而导致形态学的变化。

This study investigated the effects of extract of Cornus officinalis CO） on bone loss in spinal cord-injured rats.Forty male Wistar rats were used to establish osteoporosis induced by spinal cord injury, subsequently divided into four groups： standard control group （CG）;spinal cord-injured control （SC）; spinal cord-injured treated with low-dose extract （L group）; and spinal cord-injured treated with high-dose extract （ H group） .Biomechanical, densitometric, and morphometric analyses were performed. SC rats showed a significant decrease in bone mass, biomechanical properties, and morphometric parameters （versus CG）.CO-treated rats showed significantly higher values of inner diameter and internal and external areas of tibia diaphysis in a dose-dependent manner.We conclude that the extract of Cornus officinalis SIEB et.ZUCC treatment was able to initiate a positive bone-tissue response, might through stimulation of osteoblasts, which was able to determine the observed morphometric modifications.