P2X3受体在糖尿病神经痛动物模型中的研究进展

Progress of animal experimental research on P2X3 receptors in diabetes mellitus

糖尿病神经痛(diabetic neuropathic pain,DNP)作为临床上最常见的并发症之一,极大地影响了患者的生活质量,目前发病机制尚不明确,缺少有效的治疗方法。DNP与周围感觉神经兴奋性增强有关,涉及多种离子通道、受体表达、功能上调,已有研究表明P2X3受体参与DNP等多种神经病理痛的痛觉形成、传导和调节,本文将围绕DNP模型的建立及P2X3受体在DNP模型中的作用予以综述。

Diabetic neuropathic pain（DNP） is one of the most common complications in clinical,which influenced patients＇ daily functions greatly,without clear mechanisms and effective methods.P2X3 receptors play a pivotal role in the formation,transmission and conduction of pain under neuropathic pain models,associated with peripheral sensory nerve excitability enhancement.This paper focuses on the establishment of DNP models,and the effects of P2X3 receptors in diabetes mellitus.