多胺参与细胞程序性死亡调控的研究进展

Progresses on Regulation Roles of Polyamines in Programmed Cell Death

多胺被认为是影响细胞存活的一个关键分子。有证据显示,多胺可直接或间接参与细胞程序性死亡的调控。多胺与细胞程序性死亡直接相关,是指其参与特定的生物学过程及与导致细胞程序性死亡的分子/结构发生相互作用;间接相关,是指多胺通过调控细胞程序性死亡的代谢衍生物,如异化和互变产物来调控这一过程。此外,多胺代谢过程中的细胞毒性产物也参与到细胞程序性死亡的级联反应中。因此,对动植物中依赖于多胺的细胞程序性死亡的最新研究进展进行综述,可为进一步研究提供一些参考。

Polyamines are believed to be the pivotal molecules for cell survival, and evidences showed that polyamines are directly and indirectly involved in the regulation of programmed cell death. Direct roles of polyamines in programmed cell death include their involvement in particular biological processes, as well as their interaction with molecules or structures which are involved in programmed cell death. The indirect roles of polyamines in regulating programmed cell death are associated with their metabolic derivatives, such as catabolic and inter-conversion products. In addition, cytotoxic products of polyamines metabolism are also involved in programmed cell death cascades. Recent progresses of polyamines-dependent programmed cell death in animals and plants are reviewed.