氧化应激标记物及其在女性生殖中的应用

Oxidative Stress and Female Reproductive Health

氧化应激指机体活性氧类产生过多,超过机体内源性抗氧化防御水平而造成的一种氧化和抗氧化失衡状态,在动脉粥样硬化、糖尿病、癌症、神经退化和老化等疾病的发生发展中发挥重要作用。氧化应激会损伤女性生殖能力,与子宫内膜异位症、多囊卵巢综合征、不明原因不孕等多种生殖相关疾病有关,目前研究较多的与生殖相关的氧化应激指标有活性氧(ROS)及其相关的氧化产物丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、抗氧化的指标有超氧化物歧化酶(SOD)、总抗氧化能力(TAC)及谷胱甘肽(GSH)。综述氧化应激标记物在女性生殖中的潜在应用价值。

Oxidative stress refers to the oxidant/antioxidant imbalance in the state in the body,plays an important role in the development of atherosclerosis,diabetes,cancer,neurodegenerative,aging and other diseases. Oxidative stress can damage the female reproductive capacity,and is related to endometriosis,polycystic ovary syndrome,unexplained infertility and other reproductive-related diseases. Oxidative stress indicators such as reactive oxygen species and its associated malonaldehyde,advanced oxidation protein products,superoxide dismutase antioxidant,glutathione and total antioxidant capacity are studied more. This review summarized the potential value of oxidative stress markers in female reproduction.