受体相互作用蛋白1在颅脑创伤后神经细胞坏死性凋亡过程中的作用

The Role of Receptor-interacting Protein-1 in Neuronal Cell Necroptosis after Traumatic Brain Injury

颅脑创伤可引起多种类型的细胞发生改变,包括神经元、神经胶质细胞和其他支持细胞等,其中神经元死亡是引起神经系统退化和致死的一个主要原因,因此其机制也是近些年的研究热点。以往研究资料显示,受体相互作用蛋白(RIP)家族在介导细胞死亡过程中发挥着关键作用,尤其是RIP1在多种形式的细胞死亡过程中均扮演重要角色,包括近几年研究新发现的坏死性凋亡,即一种不依赖含半胱氨酸的天冬氨酸蛋白水解酶的程序性细胞死亡类型。

Traumatic brain injury may induce changes in multiple cell types,such as neurons,gliocytes,astricytos,and other supporting cells. However,neuron death is a major cause of the degeneration of the central nervous system,as well as death. The mechanisms of neuronal cell death have been the predominant focus. Data demonstrate that receptor-interacting protein-1 plays a key role in mediating cell death processes,and is critically involved in mediating necroptosis,a Caspase-independent pathway of programmed cell death highlighted in recent years.