期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微颗粒与内皮功能障碍 被引量：2

Study on the Relationship between Microparticles and Endothelial Dyfunction
下载PDF
导出
摘要 微颗粒是多种细胞激活、损伤或凋亡时,细胞膜脱落产生的直径<1.0μm的膜性小囊泡。研究发现,微颗粒与内皮功能障碍的关系密切,在介导内皮细胞引起的炎症反应、凝血反应、内皮舒张功能减退、新生血管生成和内皮细胞凋亡等方面发挥重要作用。微颗粒与多种心血管疾病密切相关,有可能成为多种心血管疾病各个发展阶段的重要生物学指标。 Microparticles are membranous vesicles less than one micron in diameter shed from several types of cells that are activated,injured or undergoing apoptosis. Studies have found that microparticles are closely related with endothelial dysfunction. Microparticles play an important role in promoting inflammation,coagulation,endothelium-dependent vasodilation dysfunction,angiogenesis and apoptosis that are mediated by endothelial cells. Microparticles are closely related with several cardiovascular diseases and may be proved to be the true biomarkers in different stages of cardiovascular diseases.
作者 方帆 蒋桔泉
机构地区 广州军区武汉总医院心内科
出处 《医学综述》 2015年第12期2164-2166,共3页 Medical Recapitulate
关键词 心血管疾病 微颗粒 内皮功能损伤 Cardiovascular disease Microparticles Endothelial dysfunction
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献24

  • 1Wang JM,Wang Y,Huang JY,et al.C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation[J].J Vasc Res,2007,44(3):241-248.
  • 2Boulanger CM.Microparticles,vascular function and hypertension[J].Curr Opin Nephrol Hypertens,2010,19(2):177-180.
  • 3Helal O,Defoort C,Robert S,et al.Increased levels of microparticles originating from endothelial cells,platelets and erythrocytes insubjects with metabolic syndrome:relationship with oxidative stress[J].Nutr Metab Cardiovasc Dis,2010,21(9):665-671.
  • 4Viera AJ,Mooberry M,Key NS.Microparticles in cardiovascular disease pathophysiology and outcomes[J].J Am Soc Hypertens,2012,6(4):243-252.
  • 5Rautou PE,Vion AC,Amabile N,et al.Microparticles,vascular function,and atherothrombosis[J].Cir Res,2011,109(5):593-606.
  • 6Tushuizen ME,Diamant M,Sturk A,et al.Cell-derived microparticles in the pathogenesis of cardiovascular disease friend or foe?[J].Arterioscler Thromb Vasc Biol,2011,31(1):4-9.
  • 7Diamant M,Tushuizen ME,Sturk A,et al.Cellular microparticles:new players in the field of vascular disease?[J].Eur J Clin Invest,2004,34(6):392-401.
  • 8Van Ierssel SH,Van Craenenbroeck EM,Conraads VM,et al.Flow cytometric detection of endothelial microparticles(EMP):effects of centrifugation and storage alter with the phenotype studied[J].Thromb Res,2010,125(4):332-339.
  • 9Lerman A,Zeiher AM.Endothelial function:cardiac events[J].Circulation,2005,111(3):363-368.
  • 10程飞,陶军,冯鉴强,杨春涛,王妍,张媛媛,张晓琳.内皮微颗粒通过NADPH氧化酶损伤内皮细胞功能[J].南方医科大学学报,2010,30(5):1103-1106. 被引量：11

二级参考文献15

  • 1Horstman LL, Jy W, Jimenez JJ, et al. Endothelial microparticles as markers of endothelial dysfunction[J ]. Front Biosci, 2004, 9:1118-35.
  • 2Chirinos JA, Zambrano JP, Virani SS, et al. Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men[J]. Am J Cardiol, 2005, 95(10): 1258-60.
  • 3Picein A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications [J]. Blood Rev, 2007, 21 (3): 157-71.
  • 4Koga H, Sugiyama S, Kugiyama K, et al. Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease [J]. J Ame Coll Cardiol, 2005, 45(10): 1622-30.
  • 5Brodsky SV, Zhang F, Nasjletti A, et al. Endothelium-derived microparticles impair endothelial function in vitro [J]. Am J Physiol, 2004, 286(5): H1910-15.
  • 6Mezentsev A, Merks RM, O'Riordan E, et al. Endothelial microparticles affect angiogenesis in vitro: role of oxidative stress [J]. Am J Physiol, 2005, 289(3): H1106-14.
  • 7Feng B, Chen Y, Luo Y, et al. Circulating level of microparticles and their correlation with arterial elasticity and endothelium-dependent dilation in patients with type 2 diabetes mellitus [J]. Atherosclerosis, 2009.
  • 8Terashima M, Ohashi Y, Azumi H, et al. Impact ofNAD(P)H oxidasederived reactive oxygen species on coronary arterial remodelin: a comparative intravascular ultrasound and histochemieal analysis of atherosclerotic lesions [ J ]. Circ Cardiovasc Interv, 2009, 2(3): 196-204.
  • 9Goettsch C, Goettsch W, Muller G, et al. Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells[J]. Biochem Biophy Res Commun, 2009, 380(2): 355-60.
  • 10Barry-Lane PA, Patterson C, van der Merwe M, et al. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice [J ]. J Clin Invest, 2001, 108(10): 1513-22.

共引文献10

同被引文献55

引证文献2

二级引证文献7

医学综述
2015年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部