不同剂量阿托伐他汀对老年急性冠状动脉综合征血脂及血清高敏C反应蛋白的影响

Effect of Different Doses of Atorvastatin on Lipids and Serum High Sensitivity C Reactive Protein in Elderly Patients with Acute Coronary Syndrome

目的比较不同剂量阿托伐他汀对老年急性冠状动脉综合征(ACS)患者血脂及血清高敏C反应蛋白(hs-CRP)的影响。方法将2011年1月至2013年12月在承德市中心医院老年病科就诊的160例ACS患者按照随机数字表法分为观察组和对照组,每组80例。两组患者均给予常规治疗,观察组在常规治疗基础上给予阿托伐他汀强化剂量(40 mg/d)治疗,对照组在常规治疗的基础上给予阿托伐他汀常规剂量(20 mg/d)治疗。比较两组患者治疗12周内不良事件发生率以及治疗12周总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和hs-CRP水平。结果两组不良事件发生率比较差异无统计学意义(P>0.05)。治疗12周后,观察组TC、LDL-C水平分别为(3.15±0.65)mmol/L、(2.38±0.35)mmol/L,低于对照组的(3.98±0.64)mmol/L、(3.11±0.37)mmol/L,差异有统计学意义(P<0.01);治疗12周后,观察组血清hs-CRP水平为(2.45±1.06)mg/L,显著低于对照组的(3.33±1.22)mg/L,差异有统计学意义(P<0.01)。结论阿托伐他汀强化剂量可改善血脂水平,降低血清hs-CRP水平。

Objective To compare the effect of different doses of atorvastatin for elderly patients with acute coronary syndrome in lipids and serum high sensitivity C reactive protein（ hs-CRP）. Methods A total of 160 elderly patients with acute coronary syndrome admitted to the Chengde Central Hospital from Jan. 2011 to Dec. 2013 were randomly divided into observation group（ 80 cases） and control group（ 80 cases） according to the random number table method. Both groups were given conventional treatment,while the observation group was also given intensive atorvastatin at dose 40 mg / d,and the control group was given atorvastatin at routine dose 20 mg / d. The incidence of adverse events within 12 weeks and total cholesterol（ TC）,low density lipoprotein cholesterol（ LDL-C） levels and serum hs-CRP level of the two groups at 12 weeks were compared. Results The incidence of adverse reactions of two groups was not statistically significant（ P〉0. 05）. TC,LDL-C levels of the observation group after 12 weeks of treatment were（ 3. 15 ± 0. 65） mmol / L,（ 2. 38 ±0. 35） mmol/L,which were lower than（ 3. 98 ±0. 64） mmol/L,（ 3. 11 ± 0. 37） mmol/L of the control group,the differences were statistically significant（ P〈0. 01）. The serum hs-CRP concentration of the observation group was（ 2. 45 ± 1. 06） mg / L after 12 weeks of treatment,significantly lower than（ 3. 33 ±1. 22） mg / L of the control group,the difference was statistically significant（ P〈0. 01）. Conclusion Intensive atorvastatin dose can improve the blood lipid levels,and reduce the level of serum hs-CRP.