中药治疗胆热犯胃型胃食管反流病疗效观察

Observation on the Efficacy of Traditional Chinese Medicine in Treating Gastroesophageal Reflux Disease of 'Gallbladder-heat invading stomach' Type

目的探讨中药治疗胃食管反流病(GRRD)的临床疗效及安全性。方法选取2011年3月至2014年3月在荆州市中医医院接受治疗的GERD患者80例,采用随机数字表法分为中药组和西药组,各40例。中药组给予龙胆泻肝汤合小陷胸汤加减治疗,西药组给予雷贝拉唑胶囊和多潘立酮口服治疗,两组疗程均为4周。记录两组临床疗效、证候疗效和病理疗效及不良反应发生情况。结果中药组治疗后临床总有效率为97.5%,西药组临床总有效率为82.5%,两组临床疗效比较差异有统计学意义(P<0.05);中药组证候有效率为95.0%,西药组证候有效率为77.5%,两组证候疗效比较差异有统计学意义(P<0.05);两组病理疗效比较差异无统计学意义(P>0.05)。两组在治疗期间均未见与治疗药物相关不良反应。结论龙胆泻肝汤合小陷胸汤加减治疗胆热犯胃型GERD结果部分补充不良反应情况有效。

Objective To investigate the clinical efficacy and security of traditional Chinese medicine in treating gastroesophageal reflux disease（ GERD） of‘gallbladder-heat invading stomach＇ type. Methods A total of 80 GERD patients admitted in Jingzhou Hospital of Traditional Chinese Medicine from Mar. 2011 to Mar. 2014 were randomly divided into Chinese medicine group and western medicine group. Patients in Chinese medicine group received decoctions of Long Dan Xie Gan and Xiao Xian Xiong. While patients in western medicine group received rabeprazole capsules and domperidone. The courses of treatment in both groups were 4 weeks. Clinical curative effect,symptom curative effect,and pathological curative effect of the two groups were compared. Results The total effective rate of Chinese medicine group was 97. 5%,significantly higher than 82. 5% of western medicine group,the difference was statistically significant（ P〈0. 05）; the syndrome effective rate of Chinese medicine group was 95. 0%,significantly higher than 77. 5% of western medicine group,the difference was statistically significant（ P〈0. 05）; there was no statistically significant difference of pathological curative effect between the two groups（ P〉0. 05）. There was no adverse drug reactions associated with the treatment between two groups during the treatment period. Conclusion The decoctions of Long Dan Xie Gan and Xiao Xian Xiong are safe and effective in treating GERD of‘gallbladder-heat invading stomach＇ type.