CerbB-2与胃癌微转移及预后关系研究

Research on Micro Metastasis and Prognosis Correlation Between CerbB-2 Protein and Gastric Adenocarcinoma

目的:研究胃癌患者原癌基因CerbB-2与胃癌微转移及对患者5年生存率的影响。方法:应用免疫组织化学法(IHC)检测78例早期黏膜下胃癌患者淋巴结原癌基因CerbB-2表达,并分析患者5年生存率结果。结果:78例早期黏膜下胃癌患者中11例转移,17例淋巴结微转移,相比HE染色检出率明显增高。78例患者5年生存率为95.2%,其中5例患者死于术后复发,这5例中4例为淋巴结转移复发,4例中又有1例术后HE诊断为淋巴结有转移,其余3例均发现有淋巴结的微转移;11例转移患者的5年生存率为6/11(54.54%);17例淋巴结微转移患者的5年生存率为14/17(82.35%);这50例没有微转移患者5年生存率为50/50(100%)。结论:CerbB-2基因检测78例早期黏膜下胃癌患者发生淋巴结微转移的5年生存率明显低于50例没有微转移患者,CerbB-2基因与胃癌的侵袭转移有明显的关联,这对早期发现胃癌及提高生存率有着极大意义。

Objective： To investigate the effect of CerbB-2 protein and micro transfer on the survival rate of patients for 5 years. Methods： The expression of gene CerbB-2 is detected by immunohistochemistry for 78 cases of submucosal gastric adenocarcinoma lymph nodes,and then the author analyzes the result of survival rate of patients for 5 years. Results： In 78 cases of early submucosal gastric cancer patients,11 patients have suffered metastasis and 17 patients have metastasized slightly. Compared with the HE staining,the detection rate was significantly higher. As can be seen from the results,survival rate of patients for 5 years was 95. 2% for 78 patients,5 of them died from postoperative recurrence,among them 4 patients were recurrence of lymph node metastasis,1 of 4 cases were diagnosed as lymph node metastasis by HE detect,other 3 cases were diagnosed as lymph node micro transfer by IHC detect. The 5 year survival rate of 11 patients with metastasis was 6 /11（ 54. 54%）,while the corresponding rate of 17 patients with lymph node metastasis was 14 /17（ 82. 35%）; the survival rate of 50 patients without metastasis is at 50 /50（ 100%）,（ P 0. 01）. Conclusion： Occurrence of micro transfer patients of 5 years＇ survival rate was significantly lower than 50 patients without micro metastasis by detecting CerbB-2 in 78 cases of early submucosal gastric cancer. The correlation between CerbB-2 gene and invasion and metastasis of gastric cancer is obvious,and it has great significance for early detection of gastric cancer and improving the survival rate.