奥曲肽联合不同用药方案治疗急性重症胰腺炎效果分析

Study on the effect of octreotide combined with different drugs in treatment of severe acute pancreatitis

目的探讨奥曲肽联合不同用药方案治疗急性重症胰腺炎的临床疗效,为临床治疗提供选择依据。方法选择收治的80例急性重症胰腺炎患者作为研究对象,将患者按照随机数字表法分为观察组和对照组各40例,对照组给予奥曲肽联合硫酸镁治疗,观察组在对照组治疗的基础上加用乌斯他汀治疗,比较两组患者临床疗效、血清白介素水平、临床症状恢复正常水平时间和不良反应发生率。结果观察组总有效率为82.50%,高于对照组的72.50%,两组比较差异有统计学意义(P<0.05);观察组体温、白细胞、尿淀粉酶、血淀粉酶恢复正常时间和腹痛消失时间均低于对照组,两组比较差异均有统计学意义(P<0.05);两组患者治疗后血清白介素水平均显著降低,观察组降低程度优于对照组,组间比较差异有有统计学意义(P<0.05);观察组不良反应发生率为7.50%,对照组为5.00%,两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论奥曲肽+乌斯他汀+硫酸镁显著提高了急性重症胰腺炎治疗效果,减轻了炎性反应,缩短了患者临床症状恢复时间,且患者的耐受性较好,安全有效,值得临床重视。

Objective To investigate the effect of octreotide combined with different drugs in the treatment of severe acute pancreatitis,to provide reference for clinical treatment.Methods 80 severe acute pancreatitis patients were randomly divided into observation group and control group with 40 cases in each group.The control group was treated with octreotide plus magnesium sulfate treatment.The observation group was treated based on the control group treatment plus treatment with UZ statins.The incidence of clinical curative effect,the clinical symptoms,serum interleukin levels returned to the normal level of time and adverse reaction were observed.Results The total effective rate of observation group（90%）was higher than that of control group（72.50%）.There was significant difference between two groups（P〈0.05）.The recovery,body temperature,white blood cell,serum amylase,urine amylase returned to normal time and the abdominal pain time the observation group were lower than that of the control group（P〈0.05）.The serum interleukin levels of the two group after treatment were significantly reduced（P〈0.05）.The incidence of adverse reaction of observation group and control group were 7.50% and 5%（P〉0.05）.Conclusion Octreotide＋ Ulinastatin＋ Magnesium sulfate significantly improve the treatment effect of acute severe pancreatitis,reduce inflammation,and shorten the time of recovery of patients.