摘要
目的 探讨子宫内膜异位症患者在位和异位内膜组织中组织因子的表达.方法 从广州市第十二人民医院子宫内膜异位症患者中选取50例增生期和50例分泌期患者作为观察组,另选取50例增生期和50例分泌期子宫内膜组织正常的人群作为对照组,采用免疫组织化学方法对观察组患者在位与异位内膜组织及对照组正常子宫内膜中组织因子的表达进行检测.结果 组织因子在对照组正常子宫内膜、观察组异位内膜组织和在位内膜组织中的阳性表达率分别为13.0％ （13/100）、84.0％ （84/100）和28.0％ （28/100）,组织因子在观察组异位和在位内膜组织中的阳性表达率明显高于对照组,差异有统计学意义（P＜0.05）.观察组异位内膜组织增生期组织因子的阳性表达率明显高于分泌期[94.0％（47/50）比74.0％ （37/50）],在位内膜组织增生期组织因子的阳性表达率明显低于分泌期[22.0％ （11/50）比34.0％ （17/50）],差异有统计学意义（P＜0.05）.结论 组织因子在子宫内膜异位症患者异位内膜组织中阳性表达率较高,高表达的组织因子在子宫内膜异位的治疗过程中起重要作用.
Objective To explore the expression of tissue factor in eutopic and ectopic endometrium in patients with endometriosis.Methods Totally 100 patients with endometriosis were enrolled as an observation group and 100 healthy women were selected as a control group;both groups included 50 subjects on proliferative stage of endometrium and 50 subjects on secretory stage of endometrium.Immunohistochemical method was used to measure the expression of tissue factor in eutopic and ectopic endometrial.Results The positive expression rate of tissue factor in ectopic endometrium and eutopic endometrium in observation group was higher than that in control group [84.0% （84/100）,28.0% （28/100） vs 13.0% （13/100）] （P 〈0.05）.In observation group,compared with the patients on secretory phase of endometrium,the positive expression rate of tissue factor inpatients on proliferative stage of endometrium was significant higher than that in the ectopic endometrium[94.0% （47/50） vs 74.0% （37/50）] （P 〈 0.05）,while it was significantly lower in the eutopic endometrium [22.0% （1 1/50） vs 34.0% （17/50）] （P 〈 0.05）.Conclusion The tissue factor in the ectopic endometrium is abnormally highly expressed.
出处
《中国医药》
2015年第7期1032-1034,共3页
China Medicine
基金
广东省人口和计划生育委员会科研项目（20133082）
