亚临床甲状腺功能减退症患者替代治疗前后血尿酸的变化

The Changes of Blood Uric Acid in Patients of Subclinical Hypothyroidism before and after Replacement Therapy

目的探讨分析亚临床甲状腺功能减退症患者替代治疗前后血尿酸的变化及意义。方法选取亚临床甲减患者30例作为实验组给予左旋甲状腺素(LT4)治疗,至甲状腺功能正常。对照组为体检中心的健康成年人20例。测定亚临床甲减组治疗前后与正常健康对照组的甲状腺功能、血脂水平及血尿酸水平的变化。结果亚临床甲减组治疗前与对照组相比TC、TG、LDL-C、UA明显升高,均有显著性差异(P<0.05),亚临床甲减组治疗后与治疗前相比TC、TG、LDL-C、UA明显降低,其差异均有统计学意义(P<0.05)。结论左旋甲状腺激素治疗可以降低患者的TC、TG、LDL-C、UA水平,对预防亚临床甲减患者动脉粥样硬化和冠心病的形成和发展有一定的积极作用。

Objective To investigate the changes and clinical significance in blood uric acid after levothyroxine treatment in the patients with subclinical hypothyroidism（SHO）. Methods 50 patients were included in this study, and we assessed the levels of TG 、TC 、LDL、HDL、UA in 20 euthyroid subjects（EU） and 30 patients with subclinical hypothy-roidism（SHO）. Results The levels of TG ,TC ,LDL and UA were observed significantly higher in SHO before treatment （P 〈 0.05）; the levels of TG 、 TC 、LDL and UA were observed significantly decrease after treatment （P 〈 0.05）. Conclusion The lipid metabolic disorder and UA are exist in subclinical hypothyroidism, these risk factors can be directly or indirectly bring about atherosclerosis, screening and treatment subclinical hypothyroidism can reduce glucose metabolic disorders and cardiovascular disease.