联合用药及单纯用药治疗脑梗死80例疗效比较

Effect of Combined Administration of Chlorpromazine Hydrochloride with Ozagrel on Acute Cerebral Infarction

目的探讨盐酸川芎嗪与奥扎格雷联合给药及单纯给予奥扎格雷对急性脑梗死脑血流动力学的影响及预后比较。方法将脑梗死患者80例随机分为两组,治疗组与对照组各40例,治疗组给予盐酸川芎嗪与奥扎格雷联合用药,对照组给予单纯奥扎格雷用药,均缓慢滴注,每天1次,1个月为一疗程。观察80例患者的脑血管血液流变学、血流动力学及临床症状的恢复程度。结果颈内动脉系统和椎基底动脉系统的平均血流速度(Vm)与治疗前相比均增快,血液流变学治疗前后比较,均有明显的好转,治疗后两组比较,具有显著性差异(P<0.05);治疗组有效率比对照组高(P<0.05)。结论盐酸川芎嗪与奥扎格雷联合用药,相对奥扎格雷单纯给药对治疗脑梗死效果较好。

Objective To evaluate the effects of combination therapy of chlorpromazine hydrochloride with ozagrel and monotherapy of ozagrel on the variation of regional blood flow speed and clinical manifestations of acute cerebral infarction. Methods In certain standards, 80 patients with ACI were assigned randomly to one of the following two groups： 1） ozagrel group, 2） chlorpromazine hydrochloride ＋ ozagrel group. The two groups were respectively treated with ozagrel and chlorpromazine hydrochloride ＋ ozagrel for 2 weeks once per day. And then, the variation of regional blood flow speed and blood viscosity and clinical manifestations of ACI were assessed. Results Blood viscosity and the pack of red cell significantly reduced in the two group,especially for the combination therapy group. Regional blood flow speed significantly increased in response to the two therapy, particularly for the combination therapy group. Conclusions In conclusion, these studies showed that in ACI patients the combination therapy of chlorpromazine hydrochloride and ozagrel may provide better clinical effects such as the increasing of the blood flow speed and the decreasing of the blood viscosity than monotherapy with ozagrel alone.