依帕司他用于促进糖尿病足伤口愈合的效果观察

The effect of epalrestat on promoting wound healing in patients with diabetic foot

目的:观察依帕司他用于促进糖尿病足伤口愈合的临床效果。方法:将60例糖尿病足病人随机分为观察组与对照组,每组各30例,两组患者均给予胰岛素、控制感染、改善微循环、伤口常规冲洗换药等治疗,观察组在此基础上加用依帕司他,疗程均为2个月,比较两组患者总有效率以及治疗后伤口面积缩小情况、伤口愈合时间的差异。结果:观察组总有效率为86.7%(26/30),伤口面积缩小(81.6±6.7)%,伤口愈合时间为(24.5±4.3)d;对照组总有效率为63.3%(19/30),伤口面积缩小(52.4±6.2)%,伤口愈合时间为(32.7±4.8)d,组间比较差异均有统计学意义(P<0.05)。结论:依帕司他用于促进糖尿病足伤口愈合效果明显。

Objective： To investigate the effect of epalrestat on promoting wound healing in patients with diabetic foot. Methods： 60 cases of diabetic foot were randomly divided into the control group and the observation group,with 30 cases in each group. Both groups were given the treatment of insulin,controlling infection,improving minicirculation,and routine rinsing and dressing change,but epalrestat was only administered additionally to the observation group,which lasted for 2 months. The total effective rate,the reduction situation of wound area and wound healing time were compared between the two groups. Results： The total effective rate,the reduction of wound area and wound healing time were significantly better in the observation group than those in the control group（ 86. 7% vs. 63. 3%,（ 81. 6 ± 6. 7） % vs.（ 52. 4 ± 6. 2） %,（ 24. 5 ± 4. 3） d vs.（ 32. 7 ± 4. 8） d,P〈0. 05）. Conclusion： There is a significant effect of epalrestat on promoting wound healing in patients with diabetic foot.