2型糖尿病患者血清维生素D与糖化血红蛋白水平及胰岛素抵抗的相关性

The correlation of vitamin D,HbA1c and HOMA-IR in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清维生素D(vitamin D,Vit D)水平的变化与糖化血红蛋白A1c(hemoglobin A1c,Hb A1c)及胰岛素抵抗的相关性。方法选取2014年3月至2014年8月来我院就诊的T2DM患者75例为研究组,同期健康体检者50例为对照组,检测两组中空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FIN)、Hb A1c、25羟维生素D3[25-hydroxy vitamin D3,25-(OH)D3]水平并且计算胰岛素抵抗指数(HOMA-IR),对检测结果进行统计学分析。结果 T2DM组中FPG、FIN、Hb A1c和HOMA-IR水平均高于对照组,差异均具有统计学意义(P均<0.05)。T2DM组血清25-(OH)D3水平显著低于对照组,差异具有统计学意义(P<0.05)。25-(OH)D3水平与Hb A1c和HOMA-IR均呈负相关(r=-0.548,r=-0.454,P均<0.05)。结论 2型糖尿病患者血清Vit D水平显著降低,并且与Hb A1c水平及HOMA-IR呈负相关。

Objective To discuss the relation of vitamin D with hemoglobin A1c （HbA1c） and HOMA-IR in patients with type 2 diabetes mellitus （T2DM）. Methods 75 cases T2DM patients （research group） and 50 cases healthy people （control group） were collected in our hospital from March 2014 to August 2014. The fasting plasma glucose（FPG）, fasting insulin（FIN）, HbA1c, 25-hydroxy vitamin D3[25-（OH）D3] levels of all subjects were detected and HOMA-IR was calculation , all data were analyzed statistically. Results The levels of FPG, FIN, HbA1c and HOMA-IR in T2DM group were all higher than that of control group, and the differences all had statistical significance（Pall〈0.05）. The level of 25-（OH）D3 in T2DM group was lower than that of control group, and the difference had statistical significance （P〈0.05）. The level of 25-（OH）D3 had negative correlation with HbA1c and HOMA-IR（r=-0.548, r=-0.454, Pall〈0.05）. Conclusion The level of serum VitD has a remarkably decrease in T2DM patients , and has negative correlation with HbA1c level and HOMA-IR.