Bmi1基因在胰腺癌中的表达及其临床意义

Expression of Bmi1 gene in pancreatic cancer and its clinical significance

目的探讨Bmi1基因在胰腺癌及癌旁组织中的表达。方法选取胰腺癌患者的病理组织86例,癌旁正常组织80例。应用半定量RT-PCR法检测Bmi1基因mRNA表达情况,分析其与临床病理特征及预后的关系。结果与癌旁组织相比较,Bmi1基因mRNA在胰腺癌中的表达明显升高。Bmi1基因mRNA的表达与患者的年龄、性别和分化程度无关,而与肿瘤的TNM分期、淋巴结转移以及术后3年生存率有关(P=0.019、0.006、0.002)。结论 Bmi1基因mRNA的含量高低与胰腺癌的发生、发展有显著相关性。

Objective To investigate the expression of Bmi1 gene in pancreatic cancer and adjacent tumor tissues. Methods Tissues of 86 cases of pancreatic cancer and 80 cases of adjacent tumor tissues were selected. Semi-quantitative RT-PCR was applied to detect the expression of Bmi1 gene mRNA,and its relationship with clinical pathological features and prognosis was analyzed. Results Compared to adjacent tumor tissues,Bmi1 mRNA expression level in pancreatic cancer tissues were higher. Bmi1 expression in pancreatic cancer was not correlated with the patient＇ s age,gender and differentiation（ P〉0. 05）, but there were correlations between Bmi1 expression and TNM stage,lymph node metastasis and 3-year survival rate（ P = 0. 0 1 9,0. 0 0 6,0. 002）. Conclusion The content of Bmi1 gene mRNA is significantly correlated with the incidence,development and prognosis of pancreatic cancer occurrence.