摘要
目的:通过Meta分析研究IL-10基因-819T>C位点多态性与中国人群牙周病易感性的相关性。方法:检索PubMed,CNKI和万方数据库中有关IL-10基因-819T>C位点多态性与中国人群牙周病易感性相关文献,以OR值和95%的可信区间为效应指标,应用STATA 11.0软件进行Meta分析,并对发表偏倚及敏感性分析进行检验。结果:纳入5篇文章,6个病例对照研究,共计827例牙周病患者和683例正常对照,Meta分析结果显示,总人群中,IL-10基因-819T>C位点多态性与牙周病风险之间没有显著关联(C vs.T:95%CI=0.848-1.152,P=0.882,Pheterogeneity=0.448;TCvs.TT:95%CI=0.705-1.092,P=0.241,Pheterogeneity=0.717;CCvs.TT:95%CI=0.780-1.606,P=0.541,Pheterogeneity=0.329;TC+CC vs.TT:95%CI=0.740-1.124,P=0.388,Pheterogeneity=0.595;CC vs.TT+TC:95%CI=0.856-1.694,P=0.286,Pheterogeneity=0.407)。在针对病种的亚组分析中,仍没有发现IL-10基因-819T>C位点多态性和中国人群的发病风险具有相关性。结论:IL-10基因-819T>C位点多态性多态性可能与中国人群牙周病的发生无关。
Objective： To investigate the association between IL-10 -819T〉C polymorphism and peri- odontitis risk through recta-analysis. Methods： The relevant literatures were searched. The data of genotype distributions and other information were extracted in groups of patients and healthy control. Odds ratio （OR） with 95% confidence interval （CI） and publish bias were applied with STATA 11.0 software. Results： Five published case-control studies including 827 patients with periodontitis and 683 controls were selected. Overall, no significant association between IL-10 - 819T〉C polymorphism and periodontitis risk was found in this meta-analysis （C vs. T： 95%CI=0. 848-1. 152, P=0. 882, Pheterogeneity=-0. 448; TC vs. TT： 95%CI=0. 705-1. 092, P=0. 241,Pheterogeneity=0.717; CC vs. TT： 95〉CI=0. 780-1. 606, P：0. 541, Pheterogeneity=0. 329; TC＋CC vs. TT. 95%CI=0. 740-1. 124, P=0. 388, Pheterogeneity=0. 595; CC vs. TT＋TC： 95%CI= 0. 856-1. 694, P=0. 286, Pheterogeneity= = 0. 407）. In the subgroup analysis on chronic periodontitis and aggressive periodontitis, no significant association was detected in the other genetic models. Conclusion： This meta-analysis demonstrates that IL-10 -819T〉C polymorphism may not be a risk factor for periodontitis development in Chinese population.
出处
《武汉大学学报（医学版）》
CAS
2015年第4期663-667,共5页
Medical Journal of Wuhan University
