老年2型糖尿病血尿酸水平与骨密度的相关性研究

Relationship between uric acid and bone mineral density in elderly type 2 diabetes

目的:探讨老年2型糖尿病患者(T2DM)血尿酸水平(SUA)与骨密度值(BMD)的关系。方法:测定200例(男性110例,女性90例)老年2型糖尿病患者SUA及相关临床资料,应用双能X线测定BMD,根据性别分为男性组及女性组,根据SUA水平分为高尿酸血症组及正常血尿酸组,分析各组BMD差异及SUA与BMD的相关性。结果:老年2型糖尿病患者中,男性各部位BMD均高于女性。SUA与腰椎BMD存在正相关关系(r=0.236,P<0.05),SUA是影响腰椎BMD的独立危险因素(标准偏回归系数β'=0.294,P<0.01),而体重指数和血脂水平主要影响股骨的BMD。结论:在老年T2DM患者中,维持一定的SUA水平有利于预防骨量丢失。

AIM： To study the relationship between uric acid（ SUA） and bone mineral density（BMD） in elderly type 2 diabetes. METHODS：The clinical data,SUA,and BMD（ determined by dual energy x-ray absorptiometry [DXA ]） of two hundred elderly type 2 diabetes patients were obtained. All the patients were divided into male group and female group; also they were further subdivided into hyperuricemia and normouricemia groups according to the level of SUA. The association between SUA and BMD from the respective groups were compared and analyzed RESULTS： SUA was positively related to BMD of lumbar spine（ L2-4） in elderly type 2 diabetes（ r = 0. 236, P〈0.05）. BMD of males was significantly higher than that of females.SUA was an independent risk factor for BMD of L2-4（β＇= 0. 294, P〈0.01）. BMI and HDL-C were independent risk factors for BMD of t thigh bone.CONCLUSION： Maintaining certain blood uric acid level will be helpful to prevent osteoporosis in elderly type 2 diabetes.