树突状细胞抗真菌疫苗的可行性研究进展

Research Progress of Feasibility of Dendritic Cell Antifungal Vaccines

临床上对于免疫缺陷或者免疫抑制的患者而言,真菌感染是不可忽视的问题。近十年,真菌感染致死的病例不断增多,发展抗真菌疫苗重新受到研究工作者的关注。树突状细胞(DC)是体内唯一能破解真菌信号并能将信息有效传递给不同的辅助性T淋巴细胞激活免疫反应的细胞。最新的研究表明,基于DC的靶向疫苗策略具有抗真菌潜力。本文论述了DC抗真菌疫苗策略及其可行性的研究进展。

Fungal infection is an important clinical problem for patients with immune deficiency or immunosuppres sion. With deadly fungus infection case increasing, the development of antifungal vaccine attracts the attention of researchers. Dendritic cell （DC） is the unique antigen presenting cell （APC） to trigger the antifungal immune reaction, and recent studies indicate that the targeted vaccination strategy based on DC have prospective antifungal potentials. In this paper, we review the antifungal immunity mechanism and recent development of the targeted DC antifungal strategy.