摘要
混合谱系白血病（MLL）基因位于第11号染色体长臂2区3带（11q23）,其编码产物为具有3 969个氨基酸残基的核蛋白.MLL蛋白最具特征性的功能为通过调节Hox基因表达水平决定细胞存活.急性白血病可发生MLL基因重排,其中MLL基因部分串联重复（MLL-PTD）为MLL基因重排中最为常见的形式之一,主要存在于核型正常及具有第11号染色体三体的急性髓细胞白血病（AML）中.作者拟就MLL基因结构、功能、MLL-PTD在AML发生、发展中的作用机制,及其可作为AML潜在治疗靶点等方面进行综述.
Mixed lineage leukemia （MLL） gene locats at chromosome 11q23 and encodes nucleoprotein with 3 969 amino acid residues.The most characteristic function of MLL protein is that it can regulate the expression level of Hox gene to determine cell survival.Acute leukemia could occur MLL gene rearrangements,and the MLL gene partial tandem duplication （MLL-PTD） is one of the most common forms of MLL gene rearrangement in acute leukemia.MLL-PTD mainly exists in the acute myeloid leukemia （AMLD with normal karyotype or trisomy 11.This article reviews literarues on MLL gene structure,function,the mechanism of MLL-PTD in the occurrence and development of AML and potential therapeutic targets of AML.
出处
《国际输血及血液学杂志》
CAS
2015年第3期236-239,共4页
International Journal of Blood Transfusion and Hematology
基金
国家自然科学基金资助项目（81200375）
