微小RNA调控肿瘤细胞耐药机制形成的研究进展

Research progress of microRNA regulating the formation of tumor cell resistance mechanism

目前,多数恶性肿瘤常规化疗效果差、预后不良,是困扰临床工作的重要难题,而肿瘤细胞耐药性的产生是导致化疗失败的重要原因之一.经过积极化疗后,残存肿瘤干细胞耐药性的存在,可导致肿瘤细胞对多数化学药物敏感性降低,引起肿瘤复发、转移,最终危及患者生命.肿瘤细胞耐药性的形成机制较为复杂,涉及的信号分子及信号通路相对较多,其具体机制尚未完全阐明.根据目前相关研究,微小RNA（miRNA）与肿瘤耐药性的形成高度相关.miRNA通过对耐药机制进行靶向调节,对减少肿瘤细胞耐药性形成起着非常重要的作用.笔者拟就目前miRNA调控肿瘤细胞耐药机制形成的研究进展进行综述.

At present,the poor prognosis of conventional chemotherapy for most malignant tumors is an important problem for clinical work,but the tumor cell resistance is one of the important reasons for the failure of chemotherapy.The existence of tumor stem cell resistance ean cause tumor cells to reduce the sensitivity of most chemical drugs after a positive chemotherapy,the recurrence and metastasis of tumor can ultimately endanger the patient＇s life.The formation mechanism of drug resistance of tumor cells is complex.And there are many signal molecules and signal transduction pathways related with the formation mechanism of drug resistance,but the concrete mechanism is not yet fully clarified.MicroRNA （miRNA） and the formation of tumor drug resistance are highly correlated according to relevant researches.MiRNA can targetedly regulate drug resistance mechanism and plays a very important role in reducing drug resistance of tumor cells.This article intends to review the research advances of the formation mechanism of miRNA resistant tumor cells.