氟伐他汀对脑梗死患者颈动脉粥样斑块干预治疗的临床观察

Fluorine statin cutting of cerebral infarction patients with carotid artery atheromatous plaque intervention treatment clinical observation

目的观察氟伐他汀对脑梗死患者血脂、炎性因子水平及颈动脉粥样硬化的影响。方法选择90例脑梗死患者,将患者随机分为3组,每组30人:A组(对照组)采用脑梗死常规治疗,氟伐他汀治疗组B组(40mg组)和C组(80mg组),B、C组在常规治疗基础上每晚分别口服氟伐他汀40mg、80mg。所有患者均于治疗前及治疗后6个月测定血脂、超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)水平及颈动脉粥样硬化情况。结果经过治疗6个月后,A组TC、TG、LDL-C、HDL-C、hs-CRP、MMP-9水平及颈动脉斑块积分、不稳定斑块数量、IMT较治疗前无明显改变(P>0.05);B、C两组TC、TG、LDL-C、hs-CRP、MMP-9显著下降,HDL-C升高,与A组比较差异有统计学意义(P<0.05),其中C组TC、TG、LDL-C、hs-CRP、MMP-9水平下降更明显(P<0.05);C组治疗后颈动脉斑块积分、不稳定斑块数量、IMTP明显减少,与A组比较差异有统计学意义(P<0.05),而B组下降不明显(P>0.05);三组NDS较治疗前均明显降低(P<0.05),三组之间差异有统计学意义(P<0.05)。结论氟伐他汀能有效降低脑梗死患者血脂、炎性因子水平,改善颈动脉粥样硬化,以80mg剂量效果显著。

Objective To observate fluorine statin cutting of cerebral infarction patients blood fat , inflammatory factor level and the influence of carotid artery atherosclerosis .Methods A total of 90 patients with cerebral infarction patients , the patients were randomly divided into three groups , each group of 30 people：group A （ control group ） with cerebral infarction conventional treatment , fluorine cutting statin therapy group and group B （40mg group） and C group （80 mg group）, B and C group in often treatment on the basis of every night oral fluorine cutting respectively statin 40mg, 80mg.All of the patients before treatment and after treatment in 6 months test blood fat, inflammatory factor super sensitive c-reactive protein （hs-CRP）, matrix metalloproteinase-9 （MMP-9） level and＆amp;nbsp;carotid atherosclerosis.Results After treatment for 6 months later, A set of TC, TG, LDL, HDL-C, hs-CRP, MMP-9 levels and carotid artery plaque score , number of unstable plaque , IMT have no obvious change compared with before treatment; B, C two groups of TC, TG, LDL-C, hs-CRP, MMP-9 decreased significantly , HDL-C increases, and group A more significant difference （P〈0.05）, the C group of TC, TG, LDL-C, hs-CRP, MMP-9 levels dropped more obvious （ P〈0.05）;Group C after treatment of carotid plaque integral , unstable plaque quantity , IMT significantly reduced , and A set of more statistical difference （ P〈0.05 ） , and group B did not decrease significantly （P〈0.05）; Three groups of NDS is before treatment were significantly lower （P〈0.05）, the three groups also have statistical difference （P〈0.05）.Conclusion Fluoride cutting statin can effectively reduce cerebral infarction patients blood fat , inflammatory factor level , improve the carotid artery atherosclerosis , with 80 mg dose effect is remarkable , and worth popularization and application .