癫痫1568例病因分析

Etiological analysis of 1568 cases with epilepsy

目的分析癫痫的可能病因。方法收集资料完整的癫痫病例1568例,进行病因及热性惊厥史和家族史在不同病因组的阳性率统计。采用R×C表资料的χ2检验,分析比较各组病因分布、各年龄组症状性癫痫前5位病因、不同病因或癫痫与家族史和热惊厥史的相关性。结果特发性、症状性和症状可能性癫痫组病例分布,P<0.05;3组家族史比较,P=0.000,特发性癫痫与家族史关系密切。在症状性癫痫组中非成年人组病例占大多数,与成年组比较差异有统计学意义,前5位病因排序不同。海马硬化组热性惊厥史阳性率较高与非海马硬化组比较,p=0.000。结论癫痫病因复杂,不同起病年龄段病因分布不同;特发性癫痫与遗传因素明显相关;热性惊厥史和海马硬化,海马硬化与癫痫之间亦具有显著的相关性,症状可能性癫痫需要进一步深入研究,以期找到确切病因。

ObjectiveToanalyzethepossiblecausesofepilepsyretrospectively.MethodsTocollect whole data of 1568 cases with epilepsy and summarize all causes of diseases and family history in all groups by statistical methods, in the meantime analyze top five causes of adult or juvenile patients with symptomatic epilepsy , as well as analyze correlations beteween different causes or epilepsy and family history or febrile convusion .Results Most patients were juvenile .Idiopathic cases were far less than symptomatic cases .There were differences for causes of epilepsy in different age groups .The sorting of top five causes was defferent in adult and juvenile .Idiopathic epilepsy had associated with family history significantly .The positive rates of febrile convusions in the group with hippocampal sclerosis were higher the groups with other single cause .Conclusion Epilepsy had very complicated causes.There were different etiologies in different ages .Idiopathic epilepsy was associated with genetic factors＆amp;nbsp;significantly.Febrile convusion was closely related to hippocampal sclerosis wich was closely related to temporal lobe epilepsy .we will look forward to find exact causes of the patients with probably symptomatic epilepsy by further study .