血小板水平与晚期肺癌预后的关系分析

The Correlation Analysis between Peripheral Blood Platelet Levels and Prognosis of Advanced Non-small Cell Lung Cancer

目的探讨血小板计数水平与晚期非小细胞肺癌(NSCLC)预后之间的关系。方法回顾性分析68例晚期NSCLC患者初治前的外周血小板计数水平,将其按血小板计数的高低分为:血小板升高组A(+)、血小板正常组A(-),随访并分析血小板计数水平的高低与患者性别、年龄、病理类型及临床分期的关系,并比较血小板计数水平对患者生存期的影响。采用Kaplan-Meier法进行生存分析,采用Log-Rank检验比较生存期的差异,用COX比例风险模型进行血小板升高对肺癌患者预后的影响。结果血小板计数升高与年龄、性别及肺癌的病理类型无关(P>0.05);而与临床分期有关(P<0.05)。结论肺癌患者血小板计数水平是影响晚期肺癌患者预后的诸多因素之一。

Objective To explore the relationship between the level of platelet count and prognosis of ad-vanced non-small cell lung cancer.Methods Retrospective analysis of the level of peripheral blood platelet count of 68 cases of patients with advanced non-small cell lung cancer before the first treated,follow-up and analysis of the platelet count＇s influence on the prognosis of lung cancer were made.Kaplan Meier-method was adopted to improve the survival a-nalysis,the Log-Rank test was used to compare the difference between the survival and increased platelet,COX propor-tional hazards models was used to evaluate the effect of hing peripheral blood platelet on the prognosis of patients with lung cancer.Results Platelet count had nothing to do with age,sex and pathological types of lung cancer,but was asso-ciated with clinical stage（ P〈0.05） .Conclusion The level of platelet count in patients with lung cancer is one of the many factors that affect the prognosis of patients with advanced lung cancer.Continuous dynamic observation on platelet count in patients with lung cancer contributes to the judjement of clinical condition and prognosis judgement.