磁共振T1ρ成像在原发性肝癌诊断中应用的初步探索

Preliminary Utility of Magnetic Resonance-T1ρ-Weighted Imaging in The Diagnosis of Human Primary Hepatic Carcinoma

目的探讨磁共振T1ρ成像(T1ρWI)在原发性肝癌诊断中的应用价值。方法前瞻性收集2014年1月至2014年6月期间于四川大学华西医院诊治的、经超声或CT检查确定肝脏占位并经病理学穿刺活检证实为原发性肝癌的9例患者进行磁共振扫描,包括常规T1WI平扫、T2WI平扫、T1WI增强扫描、T1ρWI平扫及T1ρWI增强扫描,比较T1ρWI平扫及T1ρWI增强扫描与其他序列的信号对比度,以探讨T1ρWI在原发性肝癌诊断中的应用价值。结果与T1ρWI平扫比较,T1WI平扫和T1WI增强扫描的信号对比度较低(t=3.532,P=0.008;t=3.666,P=0.006),而T2WI平扫信号对比度的差异无统计学意义(t=-1.448,P=0.186);与T1ρWI增强扫描比较,T1WI增强扫描的信号对比度较低(t=3.468,P=0.008)。结论 T1ρWI能较好地显示原发性肝癌病灶,有望成为新的对原发性肝癌诊断有利的磁共振扫描方式,且其是一种新的不使用造影剂的动脉成像方法。

Objective To explore the utility of magnetic resonance-T1ρ-weighted imaging （T1ρWI） in the diagnosis of human primary hepatic carcinoma. Methods Nine patients were prospectively collected from West China Hospital of Sichuan University during January 2014 and June 2014, who had liver lesion that identified by the ultrasound or CT examination, and then were verified as primary hepatic carcinoma with pathological biopsy. A routine T2WI, pre- and post-contrast T1WI, pre- and post-contrast TlpWI were performed on a 3.0 T clinical imager. The tumor-to-normal- tissue contrast was compared between pre-contrast T1ρWI/post-contrast TlpWI and other sequences respectively, to investigate the value of T1 pWI in the diagnosis of human primary hepatic carcinoma. Results The tumor-to-normal- tissue contrast of pre- and post- contrast T1WI were lower than that of pre-contrast TlpWI （t=3.532, P-0.008; t=3.666, P=0.006）, while there was no statistical difference between T2WI and pre-contrast TlpWI （t=-1.448, P=0.186）. And compared with post-contrast T1ρWI, post-contrast T1WI had lower tumor-to-normal-tissue contrast （t=3.468, P=0.008）. Conclusions T1ρWI can provide a better image of human primary hepatic carcinoma, thus T1ρWI is expected to become a new and useful method in MR scanning. It also shows potential value who can be used as an artery imaging that without using contrast agents.