HER-2/neu基因在胃癌临床研究中的进展

Clinical Research Progress of HER-2/neu Gene in Gastric Cancer

目的总结人类表皮生长因子受体2(HER-2/neu)基因的生物学特性及其在胃癌组织中的表达和意义,以及靶向HER-2/neu基因药物在胃癌治疗中的应用价值。方法收集近年来国内外公开发表的关于HER-2/neu基因与胃癌相关性的文献并进行综述。结果 HER-2/neu基因是一种编码人类表皮生长因子受体(EGFR)的基因,它通过下游信号的转导参与调控肿瘤细胞的增殖、凋亡、浸润、转移等。HER-2/neu基因扩增或HER-2蛋白过表达与胃癌的发生和发展密切相关,但其能否作为胃癌独立的预后判断因素仍有争议。目前已有多种靶向HER-2/neu基因的药物应用于临床,均取得了不错的近期疗效。结论 HER-2/neu基因是胃癌治疗的一个可靠靶点,基于HER-2/neu基因的肿瘤靶向治疗具有广阔的应用前景。

Objective To summarize the biological characteristics of human epidermal growth factor receptor 2 （HER-2/neu） gene, the expression and meaning of HER-2/neu gene in gastric cancer, and clinical application of targeted medicine of HER-2/neu gene in gastric cancer. Methods Related literatures about HER-2/neu gene and gastric cancer were retrieved for a review. Results HER-2/neu gene encoded human epidermal growth factor receptor, and it partici- pated in the gene regulation of tumor cell proliferation, invasion, and metastasis through the downstream signal transduc- tion pathway. Amplification of HER-2/neu gene or overexpression of HER-2 was closely bound up to the occurrence and development of gastric cancer, however, whether it could be used as independent prognostic factors of gastric cancer remained to be controversial. Several targeted medicine of HER-2/neu gene had applied to clinical at present, and all of them obtained good short-term effect. Conclusion HER-2/neu gene is a reliable target of gastric cancer and targeted medicine of HER-2/neu gene has a promising prospect.