双孔通道家族与钙信号调节

Two-pore Channels in the Regulation of Ca^(2+) Signal

钙离子(Ca2+)在细胞各项生理活动中发挥着重要作用.胞浆游离Ca2+浓度([Ca2+]i)的变化与细胞功能、信号转导及细胞损伤和凋亡都有密切联系.研究证实,烟酸腺嘌呤二核苷磷酸(nicotinic acid adenine dinucleotide phosphate,NAADP)是一种有效的胞内Ca2+释放活化剂,但具体作用机制尚不明确.有研究表明,双孔通道家族(two pore channels,TPCs)可能与此有关.本文对TPCs的结构与功能及其生理病理等相关性的研究进展作一综述,从而为进一步研究TPCs生理功能提供依据.

Calcium ions play an important role in the physiological activities of cells. The changes of calcium ion（ Ca2 ＋） concentration is closely related with cell function,signal transduction,tissue damage / repair and apoptosis. It has been known that nicotinic acid adenine dinucleotide phosphate（NAADP） is an effective activator for the release of intracellular Ca2 ＋,but the mechanism is still unclear. Recent studies have found that two-pore channels（ TPCs） might be involved. This review summarized the research progress about the structure and function of TPCs, as well as various physiological and pathological correlated effects. It provided useful information for further and better understanding of the physiological functions of TPCs.